Article
Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2015
Ahmed Syed Feroj, Das Nilanjana, Sarkar Moumita, Chatterjee Uttara, Chatterjee Sandip, Ghosh Mrinal Kanti
Abstract excerpt
PTEN mutation is a frequent feature across a plethora of human cancers, the hot-spot being its C-terminus (PTEN-CT) regulatory domain resulting in a much diminished protein expression. In this study, the presence of C-terminus mutations was confirmed through sequencing of different human tumor samples. The kinase CKII-mediated phosphorylation of PTEN at these sites makes it a loopy structure competing with the E3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.