Article
Endogenous antibody responsiveness to epidermal growth factor receptor is associated with immunoglobulin allotypes and overall survival of patients with glioblastoma.
Neuro-oncology - 1 May 2015
Pandey Janardan P, Kistner-Griffin Emily, Radwan Faisal F, Kaur Navtej, Namboodiri Aryan M, Black Laurel, Butler Mary Ann, Carreon Tania, Ruder Avima M
Abstract excerpt
BACKGROUND: Immunoglobulin γ marker (GM) and κ marker (KM) allotypes, hereditary antigenic determinants of γ and κ chains, respectively, have been shown to be associated with immunity to a variety of self and nonself antigens, but their possible contribution to immunity to the tumor-associated antigens epidermal growth factor receptor (EGFR) and EGFR variant (v)III has not been evaluated. The aim of the present...
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