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Article

Immunoglobulin GM allotypes as effect modifiers of cytomegalovirus-spurred neuroblastoma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2013

Pandey Janardan P

Abstract excerpt

An uncommon immunoglobulin GM (γ marker) genotype has been reported to be strongly associated with susceptibility to neuroblastoma, but the mechanism(s) underlying this association is not known. Increasing evidence implicates human cytomegalovirus (HCMV) in the pathogenesis of neuroblastoma. HCMV has evolved a large repertoire of sophisticated strategies to evade host immunosurveillance. Particular GM alleles...

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PMID: 24008491
DOI: 10.1158/1055-9965.EPI-13-0612

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