Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parathyroid-specific epidermal growth factor-receptor inactivation prevents uremia-induced parathyroid hyperplasia in mice.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2015

Arcidiacono Maria Vittoria, Yang Jing, Fernandez Elvira, Dusso Adriana

Abstract excerpt

BACKGROUND: In chronic kidney disease (CKD), parathyroid hyperplasia contributes to high serum parathyroid hormone (PTH) and also to an impaired suppression of secondary hyperparathyroidism by calcium, vitamin D and fibroblast growth factor 23 (FGF23). In rats, systemic inhibition of epidermal growth factor receptor (EGFR) activation markedly attenuated uremia-induced parathyroid hyperplasia and vitamin D...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblast Growth Factor-23
Share to Hyperplasia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Parathyroid Glands

Share to Parathyroid Hormone

Share to Receptors, Calcitriol

Share to Renal Insufficiency, Chronic

Share to Uremia

Source

Open in PubMed Open full text

Identifiers

PMID: 25324357
DOI: 10.1093/ndt/gfu318
PMCID: PMC4339687

Genes

EGFR
PTH
VDR
FGF23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parathyroid-specific epidermal growth factor-receptor inactivation prevents uremia-induced parathyroid hyperplasia in mice.PMID 25324357Read ↗

The essential roles of Dicer-mediated mTORC1 signaling in parathyroid gland integrity and function: Insights from genetic mouse models and clinical dataSemantic proximity Read ↗

Parathyroid-specific interaction of the calcium-sensing receptor and G alpha q.Semantic proximity Read ↗

Adenine-induced chronic kidney disease induces a similar skeletal phenotype in male and female C57BL/6 mice with more severe deficits in cortical bone properties of male mice.Semantic proximity Read ↗

Let-7 and MicroRNA-148 Regulate Parathyroid Hormone Levels in Secondary HyperparathyroidismSemantic proximity Read ↗

Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype.Semantic proximity Read ↗

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice.Semantic proximity Read ↗

Age-related differences in the skeletal phenotype of Brown Norway rats induced to develop chronic kidney disease.Semantic proximity Read ↗

TGF-alpha mediates genetic susceptibility to chronic kidney disease.Semantic proximity Read ↗

Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background.Semantic proximity Read ↗

Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model.Semantic proximity Read ↗

Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency.Semantic proximity Read ↗

TSH compensates thyroid-specific IGF-I receptor knockout and causes papillary thyroid hyperplasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.