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Article

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

14 Nov 2015

Abstract excerpt

Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-specific...

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PMID: 26568315
DOI: 10.7554/elife.07916

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