FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci.

doi:10.1007/BF00336750

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Article

FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci.

Current genetics - 1 Jan 1993

Barthelmess I B, Tropschug M

Abstract excerpt

Growth of Neurospora crassa wild-type is inhibited by micromolar concentrations of the immunosuppressive macrolide FK506. Spontaneous and induced mutations that confer resistance to FK506 identified two loci, fkr-1 and fkr-2. They map on the right arm of linkage group V on either side of inl with...

Topics

Alleles
Amino Acid Isomerases
Carrier Proteins
Drug Resistance, Microbial
Genes, Dominant
Genes, Fungal
Mutation
Neurospora crassa
Peptidylprolyl Isomerase
Phenotype
Tacrolimus
Tacrolimus Binding Proteins

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