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Article

Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2014

Yap Kai Lee, Kiyotani Kazuma, Tamura Kenji, Antic Tatjana, Jang Miran, Montoya Magdeline, Campanile Alexa, Yew Poh Yin, Ganshert Cory, Fujioka Tomoaki, Steinberg Gary D, O'Donnell Peter H, Nakamura Yusuke

Abstract excerpt

PURPOSE: Because of suboptimal outcomes in muscle-invasive bladder cancer even with multimodality therapy, determination of potential genetic drivers offers the possibility of improving therapeutic approaches and discovering novel prognostic indicators. EXPERIMENTAL DESIGN: Using pTN staging, we case-matched 81 patients with resected ≥pT2 bladder cancers for whom perioperative chemotherapy use and disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25316812
DOI: 10.1158/1078-0432.CCR-14-0257
PMCID: PMC4268280

Genes

ATM
BRCA1
BRCA2
ERCC2
FANCD2
PALB2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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