Primary leptomeningeal melanoma: the prognostic significance of its genetic signature and embryological origin.

Abstract excerpt

Primary leptomeningeal melanomas are rare, comprising less than one percent of all brain tumours. They are aggressive and radioresistant tumours, with a poor prognosis. The mainstay of treatment is complete surgical resection and chemotherapy with limited success. Distinguishing a primary leptomeningeal melanoma from the more common metastatic disease can be difficult, and often requires the use of ancillary...

Topics

• GTP-Binding Protein alpha Subunits
• GTP-Binding Protein alpha Subunits, Gq-G11
• Humans
• Melanoma
• Mutation
• Prognosis
• Uveal Neoplasms