Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis.

Journal of cellular and molecular medicine - 1 Jan 2015

Margheri Francesca, Papucci Laura, Schiavone Nicola, D'Agostino Riccardo, Trigari Silvana, Serratì Simona, Laurenzana Anna, Biagioni Alessio, Luciani Cristina, Chillà Anastasia, Andreucci Elena, Del Rosso Tommaso, Margheri Giancarlo, Del Rosso Mario, Fibbi Gabriella

Abstract excerpt

Gangliosides and the urokinase plasminogen activator receptor (uPAR) tipically partition in specialized membrane microdomains called lipid-rafts. uPAR becomes functionally important in fostering angiogenesis in endothelial progenitor cells (EPCs) upon recruitment in caveolar-lipid rafts. Moreover...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolae
Share to Caveolin 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colony-Forming Units Assay

Share to Endothelial Progenitor Cells

Share to G(M1) Ganglioside

Share to Membrane Microdomains

Share to Neovascularization, Physiologic

Share to Receptors, Urokinase Plasminogen Activator

Source

Open in PubMed Open full text

Identifiers

PMID: 25313007
DOI: 10.1111/jcmm.12410
PMCID: PMC4288355

Genes

SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25313007-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis.PMID 25313007Read ↗

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesisSemantic proximity Read ↗

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and CancerSemantic proximity Read ↗

Effect of Ganglioside and Tetraspanins in Microdomains on Interaction of Integrins with Fibroblast Growth Factor ReceptorSemantic proximity Read ↗

Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype.Semantic proximity Read ↗

Regulation of tumor phenotypes by caveolin-1 and sphingolipid-controlled membrane signaling complexes.Semantic proximity Read ↗

Differential expression of biofunctional GM1 and GM3 gangliosides within the plastic-adherent multipotent mesenchymal stromal cell population.Semantic proximity Read ↗

Contributions of the extracellular and cytoplasmic domains of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in regulating cell-cell localization.Semantic proximity Read ↗

The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.Semantic proximity Read ↗

Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.Semantic proximity Read ↗

Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection.Semantic proximity Read ↗

Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.