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Article

TNF-alpha-308 G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis.

The pharmacogenomics journal - 1 Jun 2009

O'Rielly D D, Roslin N M, Beyene J, Pope A, Rahman P

Abstract excerpt

Although tumor necrosis factor-alpha (TNF-alpha) blockade is a very effective therapy for rheumatoid arthritis (RA), not all patients achieve a favorable outcome. The objective of this study was to determine if the common TNF-alpha variant -308(A) predicts poor response to TNF-alpha inhibitors in RA patients using meta-analysis. Studies were identified using MEDLINE and EMBASE. Data were extracted based on DAS28...

Read the complete abstract on PubMed

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Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Pharmacogenetics

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Severity of Illness Index

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 19365401
DOI: 10.1038/tpj.2009.7

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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