Article
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.
PLoS medicine - 9 Dec 2008
Lees Charlie W, Zacharias William J, Tremelling Mark, Noble Colin L, Nimmo Elaine R, Tenesa Albert, Cornelius Jennine, Torkvist Leif, Kao John, Farrington Susan, Drummond Hazel E, Ho Gwo-Tzer, Arnott Ian D R, Appelman Henry D, Diehl Lauri, Campbell Harry, Dunlop Malcolm G, Parkes Miles, Howie Sarah E M, Gumucio Deborah L, Satsangi Jack
Abstract excerpt
BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are polygenic chronic inflammatory bowel diseases (IBD) of high prevalence that are associated with considerable morbidity. The hedgehog (HH) signalling pathway, which includes the transcription factor glioma-associated oncogene homolog 1 (GLI1), plays vital roles in gastrointestinal tract development, homeostasis, and malignancy. We identified a...
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