Article
Genetic variants in Cell Adhesion Molecule 1 (CADM1): a validation study of a novel endothelial cell venous thrombosis risk factor.
Thrombosis research - 1 Dec 2014
de Haan Hugoline G, Bezemer Irene D, Vossen Carla Y, van Hylckama Vlieg Astrid, Böehringer Stefan, Hasstedt Sandra J, Levy Samuel, Rosendaal Frits R, Bovill Edwin G
Abstract excerpt
INTRODUCTION: In a protein C deficient family, we recently identified a candidate gene, CADM1, which interacted with protein C deficiency in increasing the risk of venous thrombosis (VT). This study aimed to determine whether CADM1 variants also interact with protein C pathway abnormalities in increasing VT risk outside this family. MATERIALS AND METHODS: We genotyped over 300 CADM1 variants in the...
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