Article
Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis.
Blood - 2 Jun 2011
Smith Nicholas L, Rice Kenneth M, Bovill Edwin G, Cushman Mary, Bis Joshua C, McKnight Barbara, Lumley Thomas, Glazer Nicole L, van Hylckama Vlieg Astrid, Tang Weihong, Dehghan Abbas, Strachan David P, O'Donnell Christopher J, Rotter Jerome I, Heckbert Susan R, Psaty Bruce M, Rosendaal Frits R
Abstract excerpt
In a recent genome-wide association study, variants in 8 genes were associated with VWF level, a risk factor for venous thrombosis (VT). In an independent, population-based, case-control study of incident VT, we tested hypotheses that variants in these genes would be associated with risk. Cases were 656 women who experienced an incident VT, and controls comprised 710 women without a history of VT. DNA was...
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