Article
Thrombomodulin gene variations and thromboembolic disease.
Thrombosis and haemostasis - 1 Jul 1997
Ohlin A K, Norlund L, Marlar R A
Abstract excerpt
Thrombomodulin (TM) is the endothelial cell cofactor for protein C activation. Since deficiencies of other protein C system proteins are known to cause thrombotic disease, then defects in the gene coding for TM could be responsible for inherited thrombophilia. We have searched for mutations in the TM gene among healthy controls as well as patients with thrombophilia and identified eight patients heterozygous for...
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