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Article

APOE ε4 and risk for Alzheimer's disease: do regionally distributed white matter hyperintensities play a role?

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2014

Brickman Adam M, Schupf Nicole, Manly Jennifer J, Stern Yaakov, Luchsinger José A, Provenzano Frank A, Narkhede Atul, Razlighi Qolamreza, Collins-Praino Lyndsey, Artero Sylvaine, Akbaraly Tasnime N, Ritchie Karen, Mayeux Richard, Portet Florence

Abstract excerpt

BACKGROUND: We previously demonstrated that parietal lobe white matter hyperintensities (WMH) increase the risk for Alzheimer's disease (AD). Here, we examined whether individuals with apolipoprotein E gene (APOE ε4) have increased parietal WMH volume. METHODS: Participants were from the Washington Heights-Inwood Columbia Aging Project (WHICAP; n = 694, 47 with dementia) in northern Manhattan and the Etude Santé...

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Identifiers

PMID: 25304991
DOI: 10.1016/j.jalz.2014.07.155
PMCID: PMC4252241

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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