Article
The Src homology 3 binding domain is required for lysophosphatidic acid 3 receptor-mediated cellular viability in melanoma cells.
Cancer letters - 28 Jan 2015
Jia Wei, Tran Sterling K, Ruddick Caitlin A, Murph Mandi M
Abstract excerpt
The LPA3 receptor is a G protein-coupled receptor that binds extracellular lysophosphatidic acid and mediates intracellular signaling cascades. Although we previously reported that receptor inhibition using siRNA or chemical inhibition obliterates the viability of melanoma cells, the mechanism was unclear. Herein we hypothesized that amino acids comprising the Src homology 3 (SH3) ligand binding motif,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.