Article
The p85α regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration.
International journal of oncology - 1 May 2012
Donini Caterina F, Di Zazzo Erika, Zuchegna Candida, Di Domenico Marina, D'Inzeo Sonia, Nicolussi Arianna, Avvedimento Enrico V, Coppa Anna, Porcellini Antonio
Abstract excerpt
Phosphoinositide-3-OH kinase (PI3K) signalling regulates various cellular processes, including cell survival, growth, proliferation and motility, and is among the most frequently mutated pathways in cancer. Although the involvement of p85αPI3K SH2 domain in signal transduction has been extensively studied, the function of the SH3 domain at the N-terminus remains elusive. A serine (at codon 83) adjacent to the...
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