Article
Hsa-miR-520d converts fibroblasts into CD105+ populations.
Drugs in R&D - 1 Dec 2014
Ishihara Yoshitaka, Tsuno Satoshi, Kuwamoto Satoshi, Yamashita Taro, Endo Yusuke, Hasegawa Junichi, Miura Norimasa
Abstract excerpt
BACKGROUND: We have previously shown that hsa-miR-520d-5p can convert cancer cells into induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs) via a dedifferentiation by a demethylation mechanism. METHODS: We tested the effect of miR-520d-5p on human fibroblasts to determine whether it could be safely used in normal cells for future clinical therapeutic applications. After we transfected the...
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