Article

Unlocking cellular plasticity: Enhancing human iPSC reprogramming through bromodomain inhibition and extracellular matrix gene expression regulation

2023-10-14

Abstract excerpt

<h4>ABSTRACT</h4> The transformation of fibroblasts into epithelial cells is critical for iPSC reprogramming. In this report, we describe studies with PFI-3, a small molecule inhibitor that specifically targets the bromodomains of SMARCA2/4 and PBRM1 subunit of SWI/SNF complex, as an enhancer of iPSC reprogramming efficiency. Our findings revealed that PFI-3 induces cellular plasticity in multiple human dermal fi...

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Literature Corpus work: 075cbde8-171f-578f-bafb-87b6c219e00f
DOI: 10.1101/2023.10.13.562265

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