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Article

From pharmacogenetics to pharmacometabolomics: SAM modulates TPMT activity.

Pharmacogenomics - 1 Aug 2014

Karas-Kuželički Nataša, Šmid Alenka, Tamm Riin, Metspalu Andres, Mlinarič-Raščan Irena

Abstract excerpt

AIM: In the present study, the influence of SAM on TPMT activity in vivo on human subjects was investigated. SUBJECTS & METHODS: A total of 1017 donors from the Estonian Genome Center of the University of Tartu (Estonia) were genotyped for common TPMT variants, evaluated for TPMT activity, SAM levels, a set of 19 biochemical and ten hematological parameters and demographic data. RESULTS: After adjustment in...

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Source

Identifiers

PMID: 25303295
DOI: 10.2217/pgs.14.84

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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