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Article

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.

FEBS letters - 6 Apr 2011

Foxler Daniel E, James Victoria, Shelton Samuel J, Vallim Thomas Q de A, Shaw Peter E, Sharp Tyson V

Abstract excerpt

LIMD1 is a tumour suppressor gene (TSG) down regulated in ∼80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically, LIMD1 interacts with pRB, repressing E2F-driv...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21402070
DOI: 10.1016/j.febslet.2011.03.013
PMCID: PMC3078326

Genes

LIMD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21402070-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.PMID 21402070Read ↗

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