Article

miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma

2022-07-26

Abstract excerpt

<title>Abstract</title> <p>Background Regional lymph node and distant metastasis are the most radical causes of high mortality in penile squamous cell carcinoma (PSCC) patients. However, the available biomarkers and detailed mechanisms underlying the metastasis of PSCC remain elusive. Here, we detected that HOXD11 was upregulated in tumors, especially in metastatic lymph nodes, highlighting its role in the progr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4ea1daf-33e8-5441-9569-593910bf4b13
DOI: 10.21203/rs.3.rs-1824198/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinomaDOI 10.21203/rs.3.rs-1824198/v1Read

Exosomal Long Noncoding RNA HOXD-AS1 Promotes Prostate Cancer Metastasis via miR-361-5p/FOXM1 AxisSemantic proximity Read

HOXB9 Promotes Laryngeal Squamous Cell Carcinoma Progression by Upregulating MMP12Semantic proximity Read

Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesisSemantic proximity Read

Risk factors and molecular characterization of penile cancer: impact on prognosis and potential targets for systemic therapy.Semantic proximity Read

Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathwaySemantic proximity Read

HOXD13 suppresses prostate cancer metastasis and BMP4 ‐induced epithelial‐mesenchymal transition by inhibiting SMAD1Semantic proximity Read

miR-138-5p inhibits the malignant progression of prostate cancer by targeting FOXC1Semantic proximity Read

HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformationSemantic proximity Read

SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancerSemantic proximity Read

NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-κB signaling pathwaySemantic proximity Read

Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathwaySemantic proximity Read

Disruption of miRNA-mRNA Networks Defines Novel Molecular Signatures for Penile CarcinogenesisSemantic proximity Read