Article
Mitochondrial genome function and maternal inheritance.
Biochemical Society transactions - 1 Oct 2013
Allen John F, de Paula Wilson B M
Abstract excerpt
The persistence of mtDNA to encode a small subset of mitochondrial proteins reflects the selective advantage of co-location of key respiratory chain subunit genes with their gene products. The disadvantage of this co-location is exposure of mtDNA to mutagenic ROS (reactive oxygen species), which are by-products of aerobic respiration. The resulting 'vicious circle' of mitochondrial mutation has been proposed to...
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