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Article

Developmental defects in a Caenorhabditis elegans model for type III galactosemia.

Genetics - 1 Dec 2014

Brokate-Llanos Ana M, Monje José M, Murdoch Piedad Del Socorro, Muñoz Manuel J

Abstract excerpt

Type III galactosemia is a metabolic disorder caused by reduced activity of UDP-galactose-4-epimerase, which participates in galactose metabolism and the generation of various UDP-sugar species. We characterized gale-1 in Caenorhabditis elegans and found that a complete loss-of-function mutation is lethal, as has been hypothesized for humans, whereas a nonlethal partial loss-of-function allele causes a variety of...

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Identifiers

PMID: 25298520
DOI: 10.1534/genetics.114.170084
PMCID: PMC4256771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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