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Article

Drosophila models of phosphatidylinositol glycan biosynthesis class A congenital disorder of glycosylation (PIGA-CDG) mirror patient phenotypes.

G3 (Bethesda, Md.) - 6 Mar 2024

Thorpe Holly J, Owings Katie G, Aziz Miriam C, Haller Madelyn, Coelho Emily, Chow Clement Y

Abstract excerpt

Mutations in the phosphatidylinositol glycan biosynthesis class A (PIGA) gene cause a rare, X-linked recessive congenital disorder of glycosylation. Phosphatidylinositol glycan biosynthesis class A congenital disorder of glycosylation (PIGA-CDG) is characterized by seizures, intellectual and developmental delay, and congenital malformations. The PIGA gene encodes an enzyme involved in the first step of...

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Identifiers

PMID: 38124489
DOI: 10.1093/g3journal/jkad291
PMCID: PMC10917494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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