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Article

RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database.

Glycobiology - 1 Jan 2015

Akiyoshi Sayaka, Nomura Kazuko H, Dejima Katsufumi, Murata Daisuke, Matsuda Ayako, Kanaki Nanako, Takaki Tetsuro, Mihara Hiroyuki, Nagaishi Takayuki, Furukawa Shuhei, Ando Keiko-Gengyo, Yoshina Sawako, Mitani Shohei, Togayachi Akira, Suzuki Yoshinori, Shikanai Toshihide, Narimatsu Hisashi, Nomura Kazuya

Abstract excerpt

In this study, we selected 181 nematode glycogenes that are orthologous to human glycogenes and examined their RNAi phenotypes. The results are deposited in the Caenorhabditis elegans Glycogene Database (CGGDB) at AIST, Tsukuba, Japan. The most prominent RNAi phenotypes observed are disruptions of cell cycle progression in germline mitosis/meiosis and in early embryonic cell mitosis. Along with the previously...

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PMID: 25091817
DOI: 10.1093/glycob/cwu080
PMCID: PMC4245905

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