Article
Generalized estimating equations for genome-wide association studies using longitudinal phenotype data.
Statistics in medicine - 15 Jan 2015
Sitlani Colleen M, Rice Kenneth M, Lumley Thomas, McKnight Barbara, Cupples L Adrienne, Avery Christy L, Noordam Raymond, Stricker Bruno H C, Whitsel Eric A, Psaty Bruce M
Abstract excerpt
Many longitudinal cohort studies have both genome-wide measures of genetic variation and repeated measures of phenotypes and environmental exposures. Genome-wide association study analyses have typically used only cross-sectional data to evaluate quantitative phenotypes and binary traits. Incorporation of repeated measures may increase power to detect associations, but also requires specialized analysis methods....
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