Article
Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences.
Oncotarget - 30 Oct 2014
Kriegsmann Mark, Endris Volker, Wolf Thomas, Pfarr Nicole, Stenzinger Albrecht, Loibl Sibylle, Denkert Carsten, Schneeweiss Andreas, Budczies Jan, Sinn Peter, Weichert Wilko
Abstract excerpt
Mutational profiling of triple-negative breast cancer (TNBC) by whole exome sequencing (WES) yielded a landscape of genomic alterations in this tumor entity. However, the clinical significance of these findings remains enigmatic. Further, integration of WES in routine diagnostics using formalin-fixed paraffin-embedded (FFPE) material is currently not feasible. Therefore, we designed and validated a breast cancer...
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