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Article

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism.

Oncotarget - 15 Oct 2014

Yu Xin, Blanden Adam R, Narayanan Sumana, Jayakumar Lalithapriya, Lubin David, Augeri David, Kimball S David, Loh Stewart N, Carpizo Darren R

Abstract excerpt

UNLABELLED: NSC319726 (ZMC1) is a small molecule that reactivates mutant p53 by restoration of WT structure/function to the most common p53 missense mutant (p53-R175H). We investigated the mechanism by which ZMC1 reactivates p53-R175H and provide evidence that ZMC1: 1) restores WT structure by functioning as a zinc-metallochaperone, providing an optimal concentration of zinc to facilitate proper folding; and 2)...

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Identifiers

PMID: 25294809
DOI: 10.18632/oncotarget.2432
PMCID: PMC4253404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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