Article
Discovery of compounds that reactivate p53 mutants in vitro and in vivo.
Cell chemical biology - 15 Sept 2022
Durairaj Geetha, Demir Özlem, Lim Bryant, Baronio Roberta, Tifrea Delia, Hall Linda V, DeForest Jacob C, Lauinger Linda, Jebril Fallatah Maryam M, Yu Clinton, Bae Hosung, Lin Da-Wei, Kim Jin Kwang, Salehi Faezeh, Jang Cholsoon, Qiao Feng, Lathrop Richard H, Huang Lan, Edwards Robert, Rychnovsky Scott, Amaro Rommie E, Kaiser Peter
Abstract excerpt
The tumor suppressor p53 is the most frequently mutated protein in human cancer. The majority of these mutations are missense mutations in the DNA binding domain of p53. Restoring p53 tumor suppressor function could have a major impact on the therapy for a wide range of cancers. Here we report a virtual screening approach that identified several small molecules with p53 reactivation activities. The UCI-LC0023...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.