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Article

Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

Molecular pharmacology - 1 Jun 2017

Yu Xin, Blanden Adam, Tsang Ashley T, Zaman Saif, Liu Yue, Gilleran John, Bencivenga Anthony F, Kimball S David, Loh Stewart N, Carpizo Darren R

Abstract excerpt

Small-molecule restoration of wild-type structure and function to mutant p53 (so-called mutant reactivation) is a highly sought-after goal in cancer drug development. We previously discovered that small-molecule zinc chelators called zinc metallochaperones (ZMCs) reactivate mutant p53 by restoring zinc binding to zinc-deficient p53 mutants. The lead compound identified from the NCI-60 human tumor cell lines...

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Identifiers

PMID: 28320780
DOI: 10.1124/mol.116.107409
PMCID: PMC5438133

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