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Article

Allele-specific p53 mutant reactivation.

Cancer cell - 15 May 2012

Yu Xin, Vazquez Alexei, Levine Arnold J, Carpizo Darren R

Abstract excerpt

Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the National Cancer Institute's anticancer drug screen data, we identified two compounds from the thiosemicarbazone family that manifest increased growth inhibitory activity in mutant p53 cells, particularly for the p53(R175) mutant. Mechanistic studies reveal that NSC319726 restores WT structure and function to the...

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Identifiers

PMID: 22624712
DOI: 10.1016/j.ccr.2012.03.042
PMCID: PMC3366694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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