Article
Structure and function of the von Willebrand factor A1 domain.
Current protein & peptide science - 1 Jun 2002
Varughese Kottayil I, Celikel Reha, Ruggeri Zaverio M
Abstract excerpt
The role of von Willebrand factor (VWF) in blocking hemorrhage is centered on its ability to act as a bridging adhesive molecule between platelets and components of the extracellular matrix or other platelets. In the course of chronic vascular diseases, moreover, the same properties of VWF may become the cause of pathological thrombus formation leading to arterial occlusion. There is convincing evidence that VWF...
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