Article
Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate.
Translational psychiatry - 7 Oct 2014
Karpyak V M, Biernacka J M, Geske J R, Jenkins G D, Cunningham J M, Rüegg J, Kononenko O, Leontovich A A, Abulseoud O A, Hall-Flavin D K, Loukianova L L, Schneekloth T D, Skime M K, Frank J, Nöthen M M, Rietschel M, Kiefer F, Mann K F, Weinshilboum R M, Frye M A, Choi D S
Abstract excerpt
Acamprosate supports abstinence in some alcohol-dependent subjects, yet predictors of response are unknown. To identify response biomarkers, we investigated associations of abstinence length with polymorphisms in candidate genes in glycine and glutamate neurotransmission pathways and genes previously implicated in acamprosate response. Association analyses were conducted in the discovery sample of 225...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.