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Genetic variation in fatty acid amide hydrolase (FAAH): Associations with early drinking and smoking behaviors.

Addictive behaviors - 1 Feb 2023

Alsaafin Alaa, Chenoweth Meghan J, Sylvestre Marie-Pierre, O'Loughlin Jennifer, Tyndale Rachel F

Abstract excerpt

BACKGROUND: The endocannabinoid system is implicated in psychiatric disorders and drug dependence. Within this system, fatty acid amide hydrolase (FAAH) metabolizes endocannabinoids. Individuals with A-group genotypes (C/A or A/A) of a common FAAH variant (rs324420; C > A; Pro129Thr) have slower enzymatic activity compared to C-group individuals (C/C genotype). Slow FAAH activity is differentially associated with...

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PMID: 36403489
DOI: 10.1016/j.addbeh.2022.107545

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