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Article

Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators.

Addiction biology - 1 Jul 2009

Ooteman Wendy, Naassila Mickaël, Koeter Maarten W J, Verheul Roel, Schippers Gerard M, Houchi Hakim, Daoust Martine, van den Brink Wim

Abstract excerpt

Acamprosate and naltrexone are effective medications in the treatment of alcoholism. However, effect sizes are modest. Pharmacogenomics may improve patient-treatment-matching and effect sizes. It is hypothesized that naltrexone exerts its effect through genetic characteristics associated with the dopaminergic/opioidergic positive reinforcement system, whereas acamprosate works through the glutamatergic/GABAergic...

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Source

Identifiers

PMID: 19523047
DOI: 10.1111/j.1369-1600.2009.00159.x

Genes

DRD2
GABRA6
GABRB2
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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