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A camel-derived MERS-CoV with a variant spike protein cleavage site and distinct fusion activation properties

1 Jan 2016

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) continues to circulate in both humans and camels, and the origin and evolution of the virus remain unclear. Here we characterize the spike protein of a camel-derived MERS-CoV (NRCE-HKU205) identified in 2013, early in the MERS outbreak. NRCE-HKU205 spike protein has a variant cleavage motif with regard to the S2' fusion activation site-notably, a novel...

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PMID: 27999426
DOI: 10.1038/emi.2016.125

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