Article
No evidence for a genetic association of IRF4 with systemic lupus erythematosus in a Chinese population.
Zeitschrift fur Rheumatologie - 1 Aug 2014
Liu S-S, Ye D, Lou J, Fan Z, Ye D-Q
Abstract excerpt
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with immunological defects caused by abnormal immune regulation and excessive production of autoantibodies. Interferon regulatory factor 4 (IRF4) as a lymphocyte-restricted member of the IRF family is expressed exclusively in immune system cells and is essential for the development of T helper-2 (Th2) cells, IL17-producing T helper (Th17) cells,...
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