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Article

Fatal familial insomnia and sporadic fatal insomnia.

Handbook of clinical neurology - 1 Jan 2018

Cracco Laura, Appleby Brian S, Gambetti Pierluigi

Abstract excerpt

Fatal familial insomnia (FFI) and sporadic fatal insomnia (sFI), or thalamic form of sporadic Creutzfeldt-Jakob disease MM2 (sCJDMM2T), are prion diseases originally named and characterized in 1992 and 1999, respectively. FFI is genetically determined and linked to a D178N mutation coupled with the M129 genotype in the prion protein gene (PRNP) at chromosome 20. sFI is a phenocopy of FFI and likely its sporadic...

Topics

Adolescent
Adult
Aged
Female
History, 20th Century
History, 21st Century
Humans
Insomnia, Fatal Familial
Male
Middle Aged
Mutation
Neuroimaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prion Diseases

Prions

Young Adult

Source

Identifiers

PMID: 29887141
DOI: 10.1016/B978-0-444-63945-5.00015-5

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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