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Article

Fatal familial insomnia and sporadic fatal insomnia.

Handbook of clinical neurology - 1 Jan 2018

Cracco Laura, Appleby Brian S, Gambetti Pierluigi

Abstract excerpt

Fatal familial insomnia (FFI) and sporadic fatal insomnia (sFI), or thalamic form of sporadic Creutzfeldt-Jakob disease MM2 (sCJDMM2T), are prion diseases originally named and characterized in 1992 and 1999, respectively. FFI is genetically determined and linked to a D178N mutation coupled with the M129 genotype in the prion protein gene (PRNP) at chromosome 20. sFI is a phenocopy of FFI and likely its sporadic...

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Identifiers

PMID: 29887141
DOI: 10.1016/B978-0-444-63945-5.00015-5

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PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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