Fatal Familial Insomnia: Clinical Aspects and Molecular Alterations.

doi:10.1007/s11910-017-0743-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Fatal Familial Insomnia: Clinical Aspects and Molecular Alterations.

Current neurology and neuroscience reports - 1 Apr 2017

Llorens Franc, Zarranz Juan-José, Fischer Andre, Zerr Inga, Ferrer Isidro

Abstract excerpt

PURPOSE OF REVIEW: Fatal familiar insomnia (FFI) is an autosomal dominant inherited prion disease caused by D178N mutation in the prion protein gene (PRNP D178N) accompanied by the presence of a methionine at the codon 129 polymorphic site on the mutated allele. FFI is characterized by severe sleep disorder, dysautonomia, motor signs and abnormal behaviour together with primary atrophy of selected thalamic nuclei...

Topics

Animals
Biomarkers
Brain
Humans
Insomnia, Fatal Familial
Mutation
Prion Proteins

Source

Open in PubMed

Identifiers

PMID: 28324299
DOI: 10.1007/s11910-017-0743-0

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics