Article

Structure analysis of human Prion protein involved in Sporadic Fatal Insomnia

2018-05-04

Abstract excerpt

Prion disorders are the root cause of Transmissible Spongiform Encephalopathies (TSE), a group of lethal diseases portrayed by progressive neurodegeneration and spongiosis. In recent years, researchers have come to understand that it is not the endogenous presence of Prions itself that causes neurodegeneration, but the amount of prion proteins that accumulates in the nervous tissue, leading them to exert neurotoxi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8243a6f6-5f4f-59cc-824e-5aa71dc58315
DOI: 10.1101/314625

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure analysis of human Prion protein involved in Sporadic Fatal InsomniaDOI 10.1101/314625Read

A sleep that never comes: Prions and their role in fatal familial insomnia - a literature review.Semantic proximity Read

Fatal Familial Insomnia: Clinical Aspects and Molecular Alterations.Semantic proximity Read

The Prion Basis of Progressive Neurodegenerative DisordersSemantic proximity Read

A structural overview of the vertebrate prion proteins.Semantic proximity Read

Sporadic and familial CJD: classification and characterisation.Semantic proximity Read

Fatal familial insomnia and sporadic fatal insomnia.Semantic proximity Read

Human prion diseases.Semantic proximity Read

Prion protein conformation in a patient with sporadic fatal insomnia.Semantic proximity Read

Prions and Prion-like ProteinsSemantic proximity Read

Atomic insights into the effects of pathological mutants through the disruption of hydrophobic core in the prion protein.Semantic proximity Read

The prion diseases.Semantic proximity Read

A survey and a molecular dynamics study on the (central) hydrophobic region of prion proteins.Semantic proximity Read