Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gastric dysregulation induced by microinjection of 6-OHDA in the substantia nigra pars compacta of rats is determined by alterations in the brain-gut axis.

American journal of physiology. Gastrointestinal and liver physiology - 15 Nov 2014

Toti Luca, Travagli R Alberto

Abstract excerpt

Idiopathic Parkinson's disease (PD) is a late-onset, chronic, and progressive motor dysfunction attributable to loss of nigrostriatal dopamine neurons. Patients with PD experience significant gastrointestinal (GI) issues, including gastroparesis. We aimed to evaluate whether 6-hydroxy-dopamine (6-OHDA)-induced degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) induces gastric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Choline O-Acetyltransferase
Share to Dopamine Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine beta-Hydroxylase

Share to Dopaminergic Neurons

Share to Nitric Oxide Synthase Type I

Share to Oxidopamine

Share to Stomach

Share to Substantia Nigra

Source

Open in PubMed Open full text

Identifiers

PMID: 25277799
DOI: 10.1152/ajpgi.00258.2014
PMCID: PMC4865236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gastric dysregulation induced by microinjection of 6-OHDA in the substantia nigra pars compacta of rats is determined by alterations in the brain-gut axis.PMID 25277799Read ↗

Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitisSemantic proximity Read ↗

Exploring cognitive and affective outcomes following bilateral 6-hydroxydopamine lesions of the substance nigra or striatum in ratsSemantic proximity Read ↗

Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease.Semantic proximity Read ↗

The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tractSemantic proximity Read ↗

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.Semantic proximity Read ↗

Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitisSemantic proximity Read ↗

[Qizhiweitong particles improve the contractile phenotype of gastric smooth muscle cells in the Parkinson's disease rats with gastroparesis].Semantic proximity Read ↗

The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis.Semantic proximity Read ↗

Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.Semantic proximity Read ↗

Neuro-behavioral impact of Tourette-related striatal disinhibition in ratsSemantic proximity Read ↗

Sensory signal transduction in the vagal primary afferent neurons.Semantic proximity Read ↗

Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.