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Article

Nucleotides regulate secretion of the inflammatory chemokine CCL2 from human macrophages and monocytes.

Mediators of inflammation - 1 Jan 2014

Higgins K R, Kovacevic W, Stokes L

Abstract excerpt

CCL2 is an important inflammatory chemokine involved in monocyte recruitment to inflamed tissues. The extracellular nucleotide signalling molecules UTP and ATP acting via the P2Y2 receptor are known to induce CCL2 secretion in macrophages. We confirmed this in the human THP-1 monocytic cell line showing that UTP is as efficient as LPS at inducing CCL2 at early time points (2-6 hours). Expression and calcium...

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Identifiers

PMID: 25276053
DOI: 10.1155/2014/293925
PMCID: PMC4170906

Genes

CCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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