Article
P2Y receptor signaling regulates phenotype and IFN-alpha secretion of human plasmacytoid dendritic cells.
Blood - 15 Mar 2008
Shin Amanda, Toy Tracey, Rothenfusser Simon, Robson Neil, Vorac Julia, Dauer Marc, Stuplich Moritz, Endres Stefan, Cebon Jonathan, Maraskovsky Eugene, Schnurr Max
Abstract excerpt
Plasmacytoid dendritic cells (PDCs) play powerful regulatory roles in innate and adaptive immune responses and are a major source of type I interferon (IFN) following viral infection. During inflammation and mechanical stress, cells release nucleotides into the extracellular space where they act as signaling molecules via G protein-coupled P2Y receptors. We have previously reported on the regulation of myeloid...
Topics
- Adenosine Triphosphate
- Biomarkers
- Calcium Signaling
- Cells, Cultured
- Dendritic Cells
- Enzyme Activation
- Gene Expression Regulation
- Humans
- Interferon-alpha
- Ligands
- Phenotype
- Protein Kinase C
- Purinergic P2 Receptor Agonists