Article
CFTR mRNA expression is regulated by an upstream open reading frame and RNA secondary structure in its 5' untranslated region.
Human molecular genetics - 15 Feb 2015
Lukowski Samuel W, Rothnagel Joseph A, Trezise Ann E O
Abstract excerpt
Post-transcriptional regulation of gene expression through 5' untranslated region (5'UTR)-encoded cis-acting elements is an important mechanism for the control of protein expression levels. Through controlling specific aspects of translation initiation, expression can be tightly regulated while remaining responsive to cellular requirements. With respect to cystic fibrosis (CF), the overexpression of cystic...
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