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Article

A Regulatory Element in Intron 1 of the Cystic Fibrosis Transmembrane Conductance Regulator Gene

1 Apr 1996

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) gene exhibits a tightly regulated pattern of expression in human epithelial cells. The mechanism of this regulation is complex and is likely to involve a number of genetic elements that effect temporal and spatial expression. To date none of the elements that have been identified in the CFTR promoter regulate tissue-specific expression. We have...

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Identifiers

PMID: 8626632
DOI: 10.1074/jbc.271.17.9947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Regulatory Element in Intron 1 of the Cystic Fibrosis Transmembrane Conductance Regulator GenePMID 8626632Read ↗

The CFTR gene and regulation of its expressionSemantic proximity Read ↗

DNA polymorphisms in potential regulatory elements of the CFTR gene alter transcription factor binding.Semantic proximity Read ↗

An element in intron 1 of the CFTR gene augments intestinal expression in vivoSemantic proximity Read ↗

Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR geneSemantic proximity Read ↗

Intronic enhancers coordinate epithelial-specific looping of the active CFTR locusSemantic proximity Read ↗

CFTR mRNA expression is regulated by an upstream open reading frame and RNA secondary structure in its 5' untranslated region.Semantic proximity Read ↗

Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cellsSemantic proximity Read ↗

Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genesSemantic proximity Read ↗

CTCF mediates insulator function at the <i>CFTR</i> locusSemantic proximity Read ↗

The cystic fibrosis gene has a “housekeeping”-type promoter and is expressed at low levels in cells of epithelial originSemantic proximity Read ↗

Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR(delta508) in the lung.Semantic proximity Read ↗

Tissue-specific in vivo transcription start sites of the human and murine cystic fibrosis genesSemantic proximity Read ↗

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