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Article

Activation of the unfolded protein response by deltaF508 CFTR.

American journal of respiratory cell and molecular biology - 1 Oct 2008

Bartoszewski Rafal, Rab Andras, Jurkuvenaite Asta, Mazur Marina, Wakefield John, Collawn James F, Bebok Zsuzsa

Abstract excerpt

Environmental insults and misfolded proteins cause endoplasmic reticulum (ER) stress and activate the unfolded protein response (UPR). The UPR decreases endogenous cystic fibrosis transmembrane conductance regulator (CFTR) mRNA levels and protein maturation efficiency. Herein, we investigated the...

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Source

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Identifiers

PMID: 18458236
DOI: 10.1165/rcmb.2008-0065OC
PMCID: PMC2551705

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18458236-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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