Article
Wild-type genotypes of BRCA1 gene SNPs combined with micro-RNA over-expression in mammary tissue leading to familial breast cancer with an increased risk of distant metastases' occurrence.
Medical oncology (Northwood, London, England) - 1 Nov 2014
Medimegh Imen, Troudi Wafa, Stambouli Nejla, Khodjet-El-Khil Houssein, Baroudi Olfa, Ayari Hajer, Omrane Ines, Uhrhammer Nancy, Privat Maud, Mezlini Amel, Ayed Farhat Ben, Romdhane Khaled Ben, Mader Sylvie, Bignon Yve Jean, Elgaaied Amel Benammar
Abstract excerpt
Germ line deleterious mutations of BRCA1 gene are not the unique factor that could inactivate BRCA1 protein which leads to familial breast cancer onset with distant metastases' occurrence. The present research explores the role that could be assigned to BRCA1 SNPs to inactivate BRCA1 protein and therefore to the occurrence of familial breast cancer with an increased risk of distant metastases' occurrence. The...
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