Article
Rrp1B gene polymorphism (1307T>C) in metastatic progression of breast cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2015
Nanchari Santhoshi Rani, Cingeetham Anuradha, Meka Phannibhushann, Damineni Surekha, Tipirisetti Nageshwarao, Padala Chiranjeevi, Annamaneni Sandhya, Rani Hanumanth Surekha, Digumarthi Raghunadha Rao, Satti Vishnupriya
Abstract excerpt
Rrp1B (ribosomal RNA processing1 homolog B) is a novel candidate metastasis modifier gene in breast cancer. Functional gene assays demonstrated that a physical and functional interaction existing between Rrp1b and metastasis modifier gene SIPA1 causes reduction in the tumor growth and metastatic potential. Ectopic expression of Rrp1B modulates various metastasis predictive extra cellular matrix (ECM) genes...
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