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Article

Allosteric signalling in the outer membrane translocation domain of PapC usher.

eLife - 28 Oct 2014

Farabella Irene, Pham Thieng, Henderson Nadine S, Geibel Sebastian, Phan Gilles, Thanassi David G, Delcour Anne H, Waksman Gabriel, Topf Maya

Abstract excerpt

PapC ushers are outer-membrane proteins enabling assembly and secretion of P pili in uropathogenic E. coli. Their translocation domain is a large β-barrel occluded by a plug domain, which is displaced to allow the translocation of pilus subunits across the membrane. Previous studies suggested that this gating mechanism is controlled by a β-hairpin and an α-helix. To investigate the role of these elements in...

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Identifiers

PMID: 25271373
DOI: 10.7554/eLife.03532
PMCID: PMC4356140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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